AdvantiGen is internally developing and patenting new intellectual property and is also negotiating the licensing of existing intellectual property from multiple sources. Currently, AdvantiGen has licensed two patents from the Wisconsin Alumni Research Foundation (WARF).


1.  Wagner, J.R., et al., A light-sensing knot revealed by the structure of the chromophore-binding domain of phytochrome. Nature, 2005. 438(7066): p. 325-31.

2.  Wagner, J.R., et al., Mutational analysis of Deinococcus radiodurans bacteriophytochrome reveals key amino acids necessary for the photochromicity and proton exchange cycle of phytochromes. J Biol Chem, 2008. 283(18): p. 12212-26.


3.  Ulijasz, A.T., et al., Characterization of two thermostable cyanobacterial phytochromes reveals global movements in the chromophore-binding domain during photoconversion. J Biol Chem, 2008. 283(30): p. 21251-66.

4.  Ulijasz, A.T., et al., Cyanochromes are blue/green light photoreversible photoreceptors defined by a stable double cysteine linkage to a phycoviolobilin-type chromophore. J Biol Chem, 2009. 284(43): p. 29757-72.

5.  Auldridge, M.E., et al., Structure-guided engineering enhances a phytochrome-based infrared fluorescent protein. J Biol Chem, 2012. 287(10): p. 7000-9.

6.  Bhattacharya, S., et al., Origins of fluorescence in evolved bacteriophytochromes. J Biol
Chem, 2014. 289(46): p. 32144-52.

7.  Lehtivuori, H., et al., Removal of Chromophore-Proximal Polar Atoms Decreases Water Content and Increases Fluorescence in a Near Infrared Phytofluor. Front Mol Biosci, 2015. 2: p. 65.